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Even for horses that are familiar with riding in a trailer, being transported involves some level of stress. Horses that are unfamiliar may develop higher levels of stress through this new experience.

Various factors may cause anxiety: separation from herdmates, the sensation and sounds of being inside a moving vehicle, and the relatively close quarters of walls and partitions. Transportation in hot weather may lead to overheating and dehydration. Staying in balance when the trailer changes speed and direction is tiring, especially as the horse has very little warning that these changes are about to occur. If the trailer is not well ventilated, horses may inhale air that is full of dust and automobile fumes.

Owners can minimize stress by driving carefully and making turns and changes of speed gradually. Getting young horses used to loading and going on short trips may ease anxiety, especially if a quiet older horse shares the ride. Horses should be rested and given water periodically on long trips, and should ideally have a period of turnout or be hand-walked at the end of the trip before being put in a stall.

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